Polynucleotides or Profhilo?

Two of the most talked-about regenerative skin treatments, side by side, so you can decide which suits your skin, with help from our Southport team.

Two regenerative treatments, compared

Polynucleotides and Profhilo are both injectable treatments that improve skin quality rather than adding volume, and they are often confused. They work differently and suit different goals, so this guide compares them honestly. Both sit within our aesthetic treatments in Southport.

Which Treatment Is Right For You?

Purified DNA fragments that stimulate the skin to repair and regenerate, boosting collagen and improving texture, tone and early laxity over a course.
Course of 2 to 3, maintained every 6 to 9 months

This is suitable for those looking for:

Skin repair, under-eye rejuvenation, texture and quality
A bio-remodelling treatment made from pure hyaluronic acid that spreads through the skin to hydrate deeply and firm, improving laxity and glow.
2 sessions 4 weeks apart, maintained around every 6 months

This is suitable looking for:

Hydration, firmness and mild skin laxity

The core difference

Both improve skin quality, but polynucleotides are regenerative, prompting the skin to repair and rebuild itself, while Profhilo is primarily about deep hydration and firmness through bio-remodelling. Polynucleotides shine for skin repair and the delicate under-eye area; Profhilo excels at hydration and firming a wider area like the face or neck.

Which is right for you

If your main concern is repairing tired, crepey or damaged skin, or improving the under-eyes, polynucleotides are often the better fit. If it is overall hydration, glow and mild firmness across the face or neck, Profhilo tends to suit better. Many people are suited to either, so the best way to decide is a consultation where we assess your skin.

Can you combine them?

Yes. They complement each other well, and a plan might use both to repair and hydrate. We would sequence them sensibly across a course.

Frequently Asked Questions (FAQ)

No. Profhilo is made from hyaluronic acid and works by bio-remodelling, while polynucleotides are DNA fragments that stimulate regeneration. They are different treatments.
Polynucleotides are usually preferred for the delicate under-eye area, where they improve skin quality and crepiness.
Both are maintained with top-ups, polynucleotides around every 6 to 9 months and Profhilo around every 6 months after the initial sessions.
No. Both improve skin quality rather than adding volume or shape. If you want volume, dermal filler is the different treatment for that.
It depends on your skin and goals. We assess this at consultation and recommend the one, or the combination, that suits you.

Elevating Natural Beauty

Not sure which suits your skin? Book a consultation and we will help you choose between polynucleotides and Profhilo.

Request A Consultation

Request an appointment using the form below and one of our team members will get back to you as soon as possible. 

Every treatment at The Skin and Aesthetics House begins with an in-person consultation, where we assess your skin and goals and agree the right approach for you. Suitability is always confirmed first, and we treat only over-18s.

Request A Consultation

Request an appointment using the form below and one of our team members will get back to you as soon as possible. 

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